Category Archives: praderwillisyndrome

Nature of Prader Willi Syndrome:

  Clinical manifestation: There are two clinical phases which characterizes PWS as shown in table 1 (Zellweger, 1988):   The two clinical phases of PWS (1) Phase 1            Moderate to severe neonatal hypotonia Poor suck Difficulty in feeding Hypogonadism Marked delayed in motor milestone   Phase 2            Much less hypotonia Short stature Hyperphagia Increasing obesity… Read More »

Conclusion of Prader Willi Syndrome

  PWS is a complex disorder with variable phenotypic changes according to the age of the patient. There are numbers of Associations and Support groups are working together to give a better management to the PWS individuals e.g. Prader Willi Syndrome Association (UK) and PWSA (USA) etc. Researches are still in progress in all concerned… Read More »

Management of Prader Willi Syndrome

  Care providers of a PWS patient must understand that the intervention means the management of clinical symptoms. Because PWS undergoes different developmental changes they must understand its impact on both patient and their families. Creation of a management strategy should be drown on the condition of disease. Professional experiences and from the knowledge of… Read More »

Animal model of Prader Willi Syndrome

  Over past decade it has been noticed that structural and functional homologies extend across very distantly related species. Now day’s homology to a relevant orthologus gene is a criterion of extracting the candidency of a gene to a disease. Virtually every mouse gene has the exact counterparts as human, and the same probably do… Read More »

Introduction to Genetics of Prader Willi Syndrome

  Many of the child behavior problems and cognitive capabilities can be explained within the framework of understanding the characteristic of Prader Willi Syndrome. Society, family and hereditary factors also influence it. PWS is a disease of altered growth and development. Affected persons are potentially overweight, sexually immature, and short and developmentally delayed individuals. The… Read More »