Zolling Elison Syndrome

By | 15th May 2012

 

 

Definition:

Disorder in which severe peptic ulceration is found due to edema or hyperplasia of islet of pancrease which secrete gastrin resulting in hyperchlorhydria.

Pathology:

Tumor my be benign 40 % and malignant in 60 % cases. it may be located in stomach , duodenum ,spleen or even lymph nodes, multiple endocrine neoplasia i.e. pancreatic , pituitary and parathyroid tumor co-exist with it.

Clinical features:

  • Severe epigastric pain due to ulcer
  • Diarrhea, steatorhea
  • Bleeding
  • Perforation
  • Family history
  • Multiple endocrine neoplasia features

 

Investigations

  • Serum gastrin level
  • Serum calcium level
  • Barium sows 75% ulcer in duodenal bulb in distal duodenum or in jejujum.

 

Treatment:

  • H2 receptor blocker drugs
  • Anticolinergic drug
  • Omeprazole
  • Total gastrectomy