📝 Common Names (6 Languages)
✅ Evidence-Based Benefits
Exceptionally rich in vitamin C (20 times orange) and antioxidants. Double-blind RCT showed significant reduction in total cholesterol (-15.5%) and LDL cholesterol (-25.0%) with 500mg twice daily over 12 weeks (PMID: 22529877). Improves dyslipidemia and atherosclerosis markers. Systematic review confirms antioxidant capacity superior to many fruits (PMID: 21495900). Traditional Ayurvedic rasayana (rejuvenative) with immunomodulatory effects.
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🔬 Clinical Trials & Evidence
⚕️ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
RCT: 98 subjects, 12 weeks, significant lipid reduction
Systematic review: Antioxidant and therapeutic potential
💊 Drug Interactions
Important: Always inform your healthcare provider about all herbs and supplements you are taking.
Anticoagulants (Warfarin)
Effect: Theoretical increased bleeding risk due to vitamin C content
Mechanism: High vitamin C may affect platelet function
Action: Monitor INR if using high doses (>2g/day). Clinical significance unclear.
Antidiabetic Medications
Effect: May enhance glucose-lowering effects
Mechanism: Improves insulin sensitivity
Action: Monitor blood glucose levels. May allow medication dose reduction.
Evidence: Animal studies and preliminary clinical data
Iron Supplements
Effect: Enhances iron absorption (beneficial)
Mechanism: Vitamin C increases non-heme iron absorption
Action: Beneficial in iron deficiency anemia. Monitor in hemochromatosis.
Cholesterol Medications (Statins)
Effect: Additive lipid-lowering effects
Action: May be synergistic. Monitor lipid panel.
⚠️ Safety Information
Adverse Events
Generally safe with excellent tolerability. Mild gastrointestinal upset at very high doses (>3g/day) in <5% users. May theoretically enhance anticoagulant effects. No serious adverse events in clinical trials.
⛔ Contraindications
Caution with anticoagulants (theoretical interaction). Monitor blood glucose in diabetics. May increase iron absorption (beneficial in anemia, monitor in hemochromatosis). Safe in pregnancy at food amounts.
🧬 Mechanism of Action
High ascorbic acid content (445-1330 mg/100g) and polyphenols (gallic acid, ellagic acid, corilagin) provide potent antioxidant effects. Modulates lipid metabolism via HMG-CoA reductase inhibition. Hepatoprotective via Nrf2 pathway activation.
💊 Dosage & Administration
500-1000mg standardized extract (40% tannins) twice daily with meals. Traditional: 1-3g dried fruit powder daily or 10-20ml fresh juice. Component of Chyawanprash (1-2 teaspoons daily). Effects seen after 4-8 weeks.
⚕️ Note: Consult healthcare provider for appropriate dosing, especially if taking medications.
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Data Retrieval: November 29, 2025 | Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm