๐ Common Names (6 Languages)
โ Evidence-Based Benefits
Adaptogenic properties reducing stress and anxiety. Double-blind RCT showed 69% reduction in anxiety scores vs 11% with placebo (PMID: 23439798). Systematic review found consistent stress-reducing effects across 5 RCTs (PMID: 31517876).
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๐ฌ Clinical Trials
โ๏ธ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
NCT03252106 - Ashwagandha for anxiety, Phase 3, Completed
High-quality clinical evidence supporting traditional uses.
RCT: 64 adults, 8 weeks, 69% anxiety reduction
Additional clinical validation.
๐ Drug Interactions
Important: Always inform your healthcare provider about all herbs and supplements you are taking.
โ ๏ธ Sedatives & CNS Depressants (Benzodiazepines, Barbiturates)
Risk: Excessive sedation and drowsiness
Mechanism: Additive GABAergic effects
Action: Reduce dose of sedatives or avoid combination. Do not operate machinery
Evidence: Pharmacological studies (PMID: 28219383)
โ ๏ธ Thyroid Medications (Levothyroxine)
Risk: May increase thyroid hormone levels
Mechanism: Thyroid-stimulating properties of ashwagandha
Action: Monitor TSH and T4 levels. Avoid in hyperthyroidism
Immunosuppressants
Effect: May reduce efficacy of immunosuppressants
Action: Avoid in transplant patients or those on immunotherapy
Antidiabetic Medications
Effect: May lower blood glucose
Action: Monitor blood sugar, adjust medication as needed
Antihypertensives
Effect: May lower blood pressure
Action: Monitor BP regularly
โ ๏ธ Safety Information
Adverse Events
Generally well tolerated. Mild drowsiness (8% of users) or gastrointestinal upset (5%). Rare cases of hepatotoxicity reported (PMID: 32818573). Discontinue if liver enzyme elevation occurs.
References: PMID: 23439798
โ Contraindications
Avoid in pregnancy and breastfeeding. Caution in hyperthyroidism and autoimmune conditions. May potentiate sedatives.
๐งฌ Mechanism of Action
Withanolides modulate the HPA axis reducing cortisol secretion. GABAergic activity contributes to anxiolytic effects. Antioxidant and anti-inflammatory mechanisms.
References: PMID: 23439798
๐ Dosage & Administration
300-600 mg/day of standardized extract (5% withanolides) in divided doses. Clinical trials typically use 300mg twice daily for 8-12 weeks.
โ๏ธ Note: Always consult healthcare provider for appropriate dosing, especially if taking medications.
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Data Retrieval Date: November 29, 2025
Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm