📝 Common Names (6 Languages)
✅ Evidence-Based Benefits
Sacred seed with 1400+ years Islamic medicine use. Comprehensive meta-analysis demonstrates improved glycemic control in diabetes: HbA1c reduction -0.55%, fasting glucose -20 mg/dL (PMID: 24481161). Systematic review shows blood pressure reduction: systolic -3.8 mmHg, diastolic -2.1 mmHg (PMID: 23867046). Lipid improvement, immune support, anti-inflammatory. Prophet Muhammad: "Black seed is cure for every disease except death."
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🔬 Clinical Trials & Evidence
⚕️ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
Meta-analysis: Diabetes glycemic improvement
Systematic review: Blood pressure reduction
💊 Drug Interactions
Important: Always inform your healthcare provider about all herbs and supplements you are taking.
Antidiabetic Medications (All classes)
Effect: May lower blood glucose
Mechanism: Improves insulin sensitivity and secretion
Action: Monitor blood glucose closely. May allow medication dose reduction
Evidence: Meta-analysis (PMID: 24481161)
Antihypertensives (All classes)
Effect: May lower blood pressure (-3.8/-2.1 mmHg)
Mechanism: Calcium channel blocking, ACE inhibition
Action: Monitor BP regularly. May enhance medication effects
Evidence: Systematic review (PMID: 23867046)
Anticoagulants (Warfarin)
Effect: May enhance anticoagulant effects
Action: Monitor INR. Watch for bleeding signs
Immunosuppressants
Effect: Immunomodulatory properties may interact
Action: Consult healthcare provider before combining
Sedatives
Effect: May enhance sedative effects
Action: Use caution with CNS depressants
⚠️ Safety Information
Adverse Events
Generally safe at culinary doses (<3g/day). Higher therapeutic doses may cause mild gastrointestinal upset (~5% users). Rare allergic contact dermatitis. Topical oil may cause skin irritation. Avoid high doses (>5g/day) in pregnancy - may stimulate uterus.
⛔ Contraindications
Avoid high doses during pregnancy (may stimulate contractions). Caution with anticoagulants, antihypertensives, and diabetes medications due to additive effects. May enhance sedative effects. Discontinue 2 weeks before surgery. May lower seizure threshold in epilepsy (rare).
🧬 Mechanism of Action
Thymoquinone (30-50% of volatile oil) provides potent antioxidant, anti-inflammatory, and immunomodulatory effects. Improves insulin sensitivity and beta cell function. Lowers blood pressure via calcium channel blocking and ACE inhibition. Antioxidant capacity superior to many antioxidants.
💊 Dosage & Administration
1-3g seed powder daily OR 500-1000mg oil in capsules (typically 40-50% thymoquinone). Can add whole seeds to food. Topical oil: dilute with carrier oil for skin conditions. Traditional: 1 teaspoon seeds with honey. Effects on metabolic parameters after 8-12 weeks.
⚕️ Note: Consult healthcare provider for appropriate dosing, especially if taking medications.
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Data Retrieval: November 29, 2025 | Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm