đ Common Names (6 Languages)
â Evidence-Based Benefits
Antimicrobial and anti-inflammatory properties for skin health. RCT showed neem-based toothpaste significantly reduced plaque and gingivitis (PMID: 21911944). Traditional use for acne, eczema, and wound healing supported by clinical studies.
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đŦ Clinical Trials
âī¸ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
RCT: Neem toothpaste for gingivitis - 60 participants
High-quality clinical evidence supporting traditional uses.
Clinical trial: Neem for diabetes - pilot study
Additional clinical validation.
đ Drug Interactions
Important: Always inform your healthcare provider about all herbs and supplements you are taking.
â ī¸ Immunosuppressants (Cyclosporine, Tacrolimus)
Risk: May reduce effectiveness of immunosuppressants
Mechanism: Neem has immunostimulant properties
Action: Avoid concurrent use in transplant patients
Antidiabetic Medications
Effect: May enhance hypoglycemic effects
Action: Monitor blood glucose closely, adjust medication as needed
Evidence: Animal studies and clinical observations
Lithium
Risk: May alter lithium levels
Action: Monitor lithium levels if using neem internally
Thyroid Medications
Effect: May affect thyroid hormone levels
Action: Monitor thyroid function in long-term use
â ī¸ Safety Information
Adverse Events
Generally safe for topical use. Oral consumption of large amounts may cause nausea or vomiting. Neem oil ingestion can be toxic - avoid internal use of pure oil.
References: PMID: 23724116
â Contraindications
Avoid oral use during pregnancy and breastfeeding. Not for children <6 months. May affect fertility in high doses.
đ§Ŧ Mechanism of Action
Nimbidin and azadirachtin exhibit antimicrobial activity by disrupting bacterial cell membranes. Immunomodulatory via cytokine regulation.
References: PMID: 23724116
đ Dosage & Administration
Topical: Apply as needed. Oral leaf extract: 500mg-1g twice daily (standardized extract). Toothpaste: Use as directed.
âī¸ Note: Always consult healthcare provider for appropriate dosing, especially if taking medications.
Disclosure: This page contains affiliate links. As an Amazon Associate, we earn from qualifying purchases at no additional cost to you. This helps support our educational content.
Data Retrieval Date: November 29, 2025
Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm