đ Common Names (6 Languages)
â Evidence-Based Benefits
Evidence-based treatment for benign prostatic hyperplasia (BPH). Cochrane systematic review of 30 RCTs shows improved urinary symptoms and flow measures comparable to finasteride but with fewer adverse effects (PMID: 23152216). Meta-analysis demonstrates significant improvement in International Prostate Symptom Score (IPSS) and quality of life (PMID: 22419340). Reduces nocturia, improves peak urinary flow rate. May benefit androgenic alopecia.
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đŦ Clinical Trials & Evidence
âī¸ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
Cochrane review: 30 RCTs, BPH symptom improvement
Meta-analysis: IPSS and urinary flow benefits
đ Find More Clinical Trials
Search for additional ongoing and completed trials investigating this herb's therapeutic effects:
đĄ Research Tip: Use both common name and scientific name when searching for comprehensive results. Filter by "Completed" trials to find published outcomes.
đ Drug Interactions
â ī¸ CRITICAL SAFETY INFORMATION
Herb-drug interactions can be serious and potentially life-threatening. Always inform your healthcare provider about all herbs, supplements, and medications you are taking. The interactions listed below are supported by clinical evidence and case reports. Citations link to peer-reviewed research on PubMed.
đ Evidence-Based Interactions: Each interaction below includes research citations (PMID links) documenting the mechanism, clinical significance, and management recommendations. Click citations to access full studies.
Finasteride & Dutasteride
Effect: Similar mechanism of action
Action: May be synergistic or redundant. Consult urologist before combining
Anticoagulants & Antiplatelets
Effect: Theoretical increased bleeding risk
Action: Discontinue 2 weeks before surgery. Monitor if using with warfarin
Hormonal Contraceptives & Testosterone
Effect: Anti-androgenic effects may interact
Action: Inform healthcare provider. Monitor for hormonal effects
Alpha-blockers (Tamsulosin)
Effect: Complementary mechanisms for BPH
Action: May be used together under medical supervision
đ Key Interaction Databases & Resources
- Natural Medicines Database: Professional herb-drug interaction checker
- PubMed: Search for latest interaction research
- Drugs.com: Drug interaction checker
- Micromedex: Hospital-grade interaction database (subscription required)
đĄ Clinical Tip: Show your healthcare provider this page and the linked research citations when discussing potential interactions.
â ī¸ Safety Information
Adverse Events
Generally well tolerated with low adverse event rate (~5%). Mild gastrointestinal upset (nausea, abdominal pain) most common. Rare headache or dizziness. Significantly fewer sexual side effects compared to finasteride. No effect on PSA levels (important for prostate cancer screening).
â Contraindications
Caution before surgery (theoretical bleeding risk - discontinue 2 weeks prior). May mask prostate cancer (discuss PSA testing with doctor). Pregnancy/breastfeeding - avoid (anti-androgenic effects). May interact with hormonal medications.
đ§Ŧ Mechanism of Action
Liposterolic extract inhibits 5-alpha reductase (both type 1 and 2), reducing conversion of testosterone to dihydrotestosterone (DHT). Anti-inflammatory effects via COX and LOX inhibition. Blocks alpha-adrenergic receptors in prostate. Anti-proliferative effects on prostate tissue.
đ Dosage & Administration
160mg standardized extract twice daily (320mg total) OR 320mg once daily. Standardized to 85-95% fatty acids and sterols. Take with meals for better absorption. Clinical benefits appear after 4-8 weeks. Requires long-term therapy (minimum 3 months for full effect).
âī¸ Note: Consult healthcare provider for appropriate dosing, especially if taking medications.
đ Additional Resources
đ WHO Monograph
Available in WHO Monographs on Selected Medicinal Plants
đŦ PubMed Search
đ§Ē ClinicalTrials.gov
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Data Retrieval Date: November 29, 2025
Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm