ð Common Names (6 Languages)
â Evidence-Based Benefits
Nutrient-dense superfood with therapeutic properties. Meta-analysis of 7 RCTs shows spirulina reduces total cholesterol by 46.76mg/dL and LDL by 41.32mg/dL (PMID: 24944404). Systematic review demonstrates blood pressure reduction and improved lipid profiles (PMID: 25021423). Contains 60-70% protein, all essential amino acids, vitamin B12, iron, beta-carotene. Antioxidant capacity via phycocyanin. May benefit allergic rhinitis and boost immune function.
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ðŽ Clinical Trials & Evidence
âïļ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
Meta-analysis: 7 RCTs, significant cholesterol reduction
Review: Blood pressure and lipid benefits
ð Find More Clinical Trials
Search for additional ongoing and completed trials investigating this herb's therapeutic effects:
ðĄ Research Tip: Use both common name and scientific name when searching for comprehensive results. Filter by "Completed" trials to find published outcomes.
ð Drug Interactions
â ïļ CRITICAL SAFETY INFORMATION
Herb-drug interactions can be serious and potentially life-threatening. Always inform your healthcare provider about all herbs, supplements, and medications you are taking. The interactions listed below are supported by clinical evidence and case reports. Citations link to peer-reviewed research on PubMed.
ð Evidence-Based Interactions: Each interaction below includes research citations (PMID links) documenting the mechanism, clinical significance, and management recommendations. Click citations to access full studies.
Immunosuppressants
Effect: May reduce immunosuppressant effectiveness
Mechanism: Immune-stimulating properties
Action: Caution in transplant patients. Consult healthcare provider
Anticoagulants & Antiplatelets
Effect: May have antiplatelet effects
Action: Discontinue 2 weeks before surgery. Monitor with warfarin
Antidiabetic Medications
Effect: May lower blood glucose
Action: Monitor blood sugar levels
Thyroid Medications
Effect: High iodine content may affect thyroid
Action: Monitor thyroid function if on thyroid medications
ð Key Interaction Databases & Resources
- Natural Medicines Database: Professional herb-drug interaction checker
- PubMed: Search for latest interaction research
- Drugs.com: Drug interaction checker
- Micromedex: Hospital-grade interaction database (subscription required)
ðĄ Clinical Tip: Show your healthcare provider this page and the linked research citations when discussing potential interactions.
â ïļ Safety Information
Adverse Events
Generally very safe - consumed as food for centuries. Mild side effects: nausea, diarrhea (first few days). May cause allergic reactions in those allergic to seafood or seaweed. Contamination risk if grown in polluted water (heavy metals, microcystins). IMPORTANT: Use only products tested for contaminants. May worsen autoimmune conditions theoretically.
â Contraindications
Caution in autoimmune diseases (may stimulate immune system). Avoid in phenylketonuria (contains phenylalanine). May interact with immunosuppressants. Generally safe but ensure product purity - contaminated spirulina dangerous. Pregnancy/breastfeeding - likely safe but ensure certified product. May affect blood clotting - discontinue before surgery.
𧎠Mechanism of Action
Phycocyanin (blue pigment-protein) provides: (1) Potent antioxidant and anti-inflammatory effects, (2) Immune modulation via increased NK cells and interferon, (3) Lipid-lowering via enhanced lipoprotein lipase activity, (4) Neuroprotective effects, (5) Detoxification support. High protein aids tissue repair.
ð Dosage & Administration
1-8g daily in divided doses. Standard: 3-4g (1 teaspoon) daily. For cholesterol: 4.5g daily. For blood pressure: 3.5-4.5g daily. Available as powder, tablets, capsules. Start with 1g and increase gradually. Best taken with meals. Ensure product certified for purity (heavy metals, microcystins tested). Organic certification preferred.
âïļ Note: Consult healthcare provider for appropriate dosing, especially if taking medications.
ð Additional Resources
ð WHO Monograph
Available in WHO Monographs on Selected Medicinal Plants
ðŽ PubMed Search
𧊠ClinicalTrials.gov
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Data Retrieval Date: November 29, 2025
Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm