📝 Common Names (6 Languages)
✅ Evidence-Based Benefits
Adaptogenic and immunomodulatory effects. RCT of 158 participants showed significant improvement in stress and anxiety symptoms (PMID: 28236410). Traditionally used for thousands of years in Ayurvedic medicine for immune support and stress reduction.
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🔬 Clinical Trials
⚕️ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
RCT: 158 participants for stress/anxiety, significant improvement
High-quality clinical evidence supporting traditional uses.
Clinical study: Metabolic stress, 40 subjects
Additional clinical validation.
💊 Drug Interactions
Important: Always inform your healthcare provider about all herbs and supplements you are taking.
Anticoagulants (Warfarin)
Risk: May enhance anticoagulant effects
Mechanism: Eugenol may inhibit platelet aggregation
Action: Monitor INR, watch for bleeding signs
Antidiabetic Medications
Effect: May lower blood glucose
Action: Monitor blood sugar levels closely
Evidence: Animal and clinical studies (PMID: 29460722)
Pentobarbital (Sedatives)
Effect: May prolong sleeping time
Action: Use caution with CNS depressants
CYP450 Substrates
Effect: May affect drug metabolism
Action: Monitor effectiveness of medications metabolized by liver
⚠️ Safety Information
Adverse Events
Generally safe with minimal adverse effects. Potential mild hypoglycemic effect requires monitoring in diabetics. Animal studies suggest high doses may affect fertility (conservative approach in pregnancy).
References: PMID: 28236410
⛔ Contraindications
Avoid in pregnancy (theoretical concern based on animal data). May enhance effects of anticoagulants. Monitor blood glucose in diabetics.
🧬 Mechanism of Action
Eugenol and ursolic acid provide antioxidant and anti-inflammatory effects via NF-κB pathway modulation. Adaptogenic via HPA axis regulation.
References: PMID: 28236410
💊 Dosage & Administration
300-600 mg/day of extract or 2-3 cups tea daily. Fresh leaves: 2-3 leaves chewed daily (traditional use). Standardized extract: 300mg twice daily.
⚕️ Note: Always consult healthcare provider for appropriate dosing, especially if taking medications.
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Data Retrieval Date: November 29, 2025
Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm