π Common Names (6 Languages)
β Evidence-Based Benefits
Sleep improvement and mild anxiolytic effects. Systematic review of 18 RCTs shows modest benefit for sleep quality and latency (PMID: 16796734). May reduce anxiety symptoms (PMID: 18729534).
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π¬ Clinical Trials
βοΈ Evidence-Based Research: Clinical trials provide the highest level of evidence for herbal efficacy and safety. The trials listed below represent peer-reviewed research registered on ClinicalTrials.gov. Each trial includes detailed protocols, patient populations, interventions tested, and measurable outcomes. Click links to access full trial details and published results.
Systematic review: 18 RCTs for sleep disorders
Cochrane review (methodological limitations noted)
π Drug Interactions
Important: Always inform your healthcare provider about all herbs and supplements.
β οΈ Sedatives & CNS Depressants (Benzodiazepines, Barbiturates, Z-drugs)
Risk: Excessive sedation, impaired cognition
Mechanism: Additive GABAergic effects
Action: AVOID combination or reduce doses significantly. Do not drive
Evidence: Pharmacological studies
β οΈ Alcohol
Risk: Excessive sedation, impaired judgment
Action: Avoid alcohol when using valerian
Antidepressants (SSRIs, Tricyclics)
Effect: Possible additive sedation
Action: Use caution, monitor for excessive drowsiness
Antihistamines (Diphenhydramine)
Effect: Increased sedation
Action: Avoid combination or use lower doses
Hepatotoxic Medications
Effect: Theoretical increased liver stress
Action: Monitor liver function if using long-term
β οΈ Safety Information
Adverse Events
Generally safe. Morning drowsiness in some users (~10%). Rare paradoxical stimulation. Hepatotoxicity in rare case reports (causality unclear). Withdrawal symptoms if stopped abruptly after long-term use.
β Contraindications
Avoid in pregnancy and breastfeeding. Caution with sedatives, alcohol, and CNS depressants. May impair driving. Discontinue before surgery.
𧬠Mechanism of Action
Valerenic acid and constituents enhance GABA-A receptor activity promoting sedation. May involve adenosine and serotonin pathways.
π Dosage & Administration
400-900mg extract before bedtime. Commission E approved dose: 2-3g dried root. May take 2-4 weeks for full effect.
βοΈ Note: Consult healthcare provider, especially if taking medications.
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Data Retrieval: November 29, 2025 | Compiled by: Sheraz Ahmed
License: CC BY-SA 4.0
Citation: Ahmed, S. (2025). Medicinal Herbs Database. Clinical Corner. https://welovelmc.com/medical-tools.htm