1. A 55-year-old man presents with fatigue and jaundice. Laboratory tests reveal elevated AST, ALT, and bilirubin levels. Hepatitis C antibody is positive, and HCV RNA is detected. Which of the following is the most appropriate next step in management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
2. A 45-year-old woman with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
3. A 60-year-old man with cirrhosis secondary to hepatitis C presents with ascites and hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
4. A 50-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
5. A 35-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
6. A 65-year-old man with cirrhosis secondary to hepatitis C presents with variceal bleeding. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
7. A 40-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
8. A 25-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
9. A 70-year-old man with cirrhosis secondary to hepatitis C presents with hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
10. A 30-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
11. A 45-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
12. A 60-year-old woman with cirrhosis secondary to hepatitis C presents with variceal bleeding. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
13. A 35-year-old man with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
14. A 50-year-old woman with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
15. A 65-year-old man with cirrhosis secondary to hepatitis C presents with hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
16. A 40-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
17. A 55-year-old man with cirrhosis secondary to hepatitis C presents with variceal bleeding. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
18. A 30-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
19. A 45-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
20. A 60-year-old woman with cirrhosis secondary to hepatitis C presents with hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
21. A 35-year-old man with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
22. A 50-year-old woman with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
23. A 65-year-old man with cirrhosis secondary to hepatitis C presents with variceal bleeding. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
24. A 40-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
25. A 55-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
26. A 60-year-old woman with cirrhosis secondary to hepatitis C presents with hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
27. A 35-year-old man with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
28. A 50-year-old woman with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
29. A 65-year-old man with cirrhosis secondary to hepatitis C presents with variceal bleeding. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
30. A 40-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
31. A 55-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
32. A 60-year-old woman with cirrhosis secondary to hepatitis C presents with hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
33. A 35-year-old man with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
34. A 50-year-old woman with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
35. A 65-year-old man with cirrhosis secondary to hepatitis C presents with variceal bleeding. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
36. A 40-year-old woman with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
37. A 55-year-old man with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program
38. A 60-year-old woman with cirrhosis secondary to hepatitis C presents with hepatic encephalopathy. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver transplantation
E. Recommend supportive care only
39. A 35-year-old man with chronic hepatitis C is found to have a sustained virologic response (SVR) after completing a course of direct-acting antiviral (DAA) therapy. Which of the following is the most appropriate management?
A. Continue to monitor liver enzymes and HCV RNA every 6 months
B. Repeat HCV RNA testing in 1 year
C. Recommend liver transplantation
D. Recommend regular screening for hepatocellular carcinoma
E. Recommend treatment with pegylated interferon and ribavirin
40. A 50-year-old woman with a history of intravenous drug use is found to have positive hepatitis C antibody and detectable HCV RNA on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with pegylated interferon and ribavirin
B. Initiate treatment with sofosbuvir and ledipasvir
C. Initiate treatment with elbasvir and grazoprevir
D. Recommend liver biopsy
E. Recommend referral to addiction treatment program