1. A 65-year-old man with cirrhosis secondary to hepatitis C is found to have a 3 cm liver mass on routine abdominal imaging. Which of the following is the most appropriate next step in management?
A. Initiate treatment with sorafenib
B. Perform contrast-enhanced CT or MRI of the abdomen
C. Recommend liver biopsy
D. Recommend liver transplantation
E. Recommend radiofrequency ablation
2. A 55-year-old woman with cirrhosis secondary to nonalcoholic steatohepatitis (NASH) presents with a 5 cm liver mass and new-onset abdominal pain. Which of the following is the most appropriate management?
A. Initiate treatment with lenvatinib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radioembolization
E. Recommend surgical resection
3. A 70-year-old man with Child-Pugh class B cirrhosis secondary to alcohol abuse is found to have multiple liver masses on routine screening. Which of the following is the most appropriate management?
A. Initiate treatment with atezolizumab and bevacizumab
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend stereotactic body radiation therapy (SBRT)
E. Recommend transarterial chemoembolization (TACE)
4. A 60-year-old woman with decompensated cirrhosis secondary to primary biliary cholangitis presents with a 2 cm liver mass and portal vein thrombosis. Which of the following is the most appropriate management?
A. Initiate treatment with sorafenib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radioembolization
E. Recommend transarterial chemoembolization (TACE)
5. A 50-year-old man with compensated cirrhosis secondary to hepatitis B is found to have a 4 cm liver mass with elevated alpha-fetoprotein levels. Which of the following is the most appropriate management?
A. Initiate treatment with lenvatinib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radiofrequency ablation
E. Recommend surgical resection
6. A 75-year-old woman with Child-Pugh class C cirrhosis secondary to alcohol abuse develops multiple liver masses. Which of the following is the most appropriate management?
A. Initiate treatment with atezolizumab and bevacizumab
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend supportive care only
E. Recommend transarterial chemoembolization (TACE)
7. A 55-year-old man with cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is found to have a 3 cm liver mass with vascular invasion on imaging. Which of the following is the most appropriate management?
A. Initiate treatment with sorafenib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radioembolization
E. Recommend surgical resection
8. A 65-year-old woman with Child-Pugh class B cirrhosis secondary to primary biliary cholangitis presents with a 6 cm liver mass and new-onset ascites. Which of the following is the most appropriate management?
A. Initiate treatment with lenvatinib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend stereotactic body radiation therapy (SBRT)
E. Recommend transarterial chemoembolization (TACE)
9. A 45-year-old man with compensated cirrhosis secondary to hepatitis B is found to have a 2 cm liver mass with elevated alpha-fetoprotein levels. Which of the following is the most appropriate management?
A. Initiate treatment with atezolizumab and bevacizumab
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radiofrequency ablation
E. Recommend surgical resection
10. A 70-year-old man with decompensated cirrhosis secondary to alcohol abuse develops multiple liver masses. Which of the following is the most appropriate management?
A. Initiate treatment with sorafenib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend supportive care only
E. Recommend transarterial chemoembolization (TACE)
11. A 60-year-old woman with cirrhosis secondary to primary sclerosing cholangitis is found to have a 4 cm liver mass with portal vein invasion on imaging. Which of the following is the most appropriate management?
A. Initiate treatment with lenvatinib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radioembolization
E. Recommend surgical resection
12. A 55-year-old man with Child-Pugh class C cirrhosis secondary to hepatitis C presents with a 2 cm liver mass and new-onset ascites. Which of the following is the most appropriate management?
A. Initiate treatment with atezolizumab and bevacizumab
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend stereotactic body radiation therapy (SBRT)
E. Recommend transarterial chemoembolization (TACE)
13. A 50-year-old woman with compensated cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is found to have a 3 cm liver mass with elevated alpha-fetoprotein levels. Which of the following is the most appropriate management?
A. Initiate treatment with sorafenib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radiofrequency ablation
E. Recommend surgical resection
14. A 65-year-old man with decompensated cirrhosis secondary to primary biliary cholangitis develops multiple liver masses. Which of the following is the most appropriate management?
A. Initiate treatment with lenvatinib
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend supportive care only
E. Recommend transarterial chemoembolization (TACE)
15. A 60-year-old woman with Child-Pugh class B cirrhosis secondary to hepatitis B is found to have a 5 cm liver mass with vascular invasion on imaging. Which of the following is the most appropriate management?
A. Initiate treatment with atezolizumab and bevacizumab
B. Recommend liver biopsy
C. Recommend liver transplantation
D. Recommend radioembolization
E. Recommend surgical resection