MCQs on clinical trials (40 Questions) By drsheraz | April 19, 2025 0 Comment Clinical Trial MCQs – 40 Questions Clinical Trial MCQs (40 Questions) Q1: What type of clinical trial compares a new treatment to an existing standard treatment? Open label trial Single blind trial Double blind trial Randomized controlled trial Explanation: Randomized controlled trials (RCTs) compare new treatments to existing standards using random assignment to minimize bias. Q2: Which phrase best describes the purpose of a placebo in a clinical trial? To test for side effects of a treatment To act as a comparison against the experimental treatment To determine the efficacy of a treatment To establish adverse event profiles Explanation: Placebos are used as control to help isolate the treatment effect from psychological effects. Q3: Which type of clinical trial requires participants and investigators to remain unaware of treatment assignment? Open label trial Single blind trial Double blind trial Crossover trial Explanation: Double-blind trials help reduce both participant and researcher bias during outcome evaluation. Q4: In which phase of clinical trials is a treatment first tested in humans? Phase 0 Phase 1 Phase 2 Phase 3 Explanation: Phase 1 trials are the first stage of human testing, focusing on safety and dosage. Q5: What type of clinical trial designs assess more than two treatment groups? Parallel design Crossover design Factorial design All of the above Explanation: All listed designs may involve more than two groups depending on structure and comparison. Q6: What methodology is used in clinical trials to randomly assign participants to treatment groups? Blinding Stratification Randomization Block randomization Explanation: Randomization is essential for minimizing allocation bias and confounding. Q7: Why is informed consent regarded as ethically important in clinical trials? To protect participants and their rights To maintain blinding and objectivity of trial To empower researchers over participants To ensure generalizability of findings Explanation: Informed consent ensures participants voluntarily participate with full understanding of risks and benefits. Q8: What is the primary purpose of a pilot clinical trial? Establish safety and efficacy of a treatment Determine optimal trial procedures and assessments Generate hypotheses for future trials Screen potential participants Explanation: Pilot trials are conducted to test trial logistics and procedures before full-scale implementation. Q9: Who is responsible for monitoring safety data during a clinical trial? Sponsor Principal investigator Data safety monitoring board Institutional review board Explanation: The Data Safety Monitoring Board (DSMB) independently reviews trial safety and efficacy data. Q10: What document must be prepared prior to initiating a clinical trial? Informed consent form Study protocol Case report form Statistical analysis plan Explanation: The study protocol outlines all trial details and must be approved before initiation. Q11: What type of clinical trial compares a new treatment to an existing standard treatment? Open label trial Single blind trial Double blind trial Randomized controlled trial Explanation: Randomized controlled trials (RCTs) compare new treatments to existing standards using random assignment to minimize bias. Q12: Which phrase best describes the purpose of a placebo in a clinical trial? To test for side effects of a treatment To act as a comparison against the experimental treatment To determine the efficacy of a treatment To establish adverse event profiles Explanation: Placebos are used as control to help isolate the treatment effect from psychological effects. Q13: Which type of clinical trial requires participants and investigators to remain unaware of treatment assignment? Open label trial Single blind trial Double blind trial Crossover trial Explanation: Double-blind trials help reduce both participant and researcher bias during outcome evaluation. Q14: In which phase of clinical trials is a treatment first tested in humans? Phase 0 Phase 1 Phase 2 Phase 3 Explanation: Phase 1 trials are the first stage of human testing, focusing on safety and dosage. Q15: What type of clinical trial designs assess more than two treatment groups? Parallel design Crossover design Factorial design All of the above Explanation: All listed designs may involve more than two groups depending on structure and comparison. Q16: What methodology is used in clinical trials to randomly assign participants to treatment groups? Blinding Stratification Randomization Block randomization Explanation: Randomization is essential for minimizing allocation bias and confounding. Q17: Why is informed consent regarded as ethically important in clinical trials? To protect participants and their rights To maintain blinding and objectivity of trial To empower researchers over participants To ensure generalizability of findings Explanation: Informed consent ensures participants voluntarily participate with full understanding of risks and benefits. Q18: What is the primary purpose of a pilot clinical trial? Establish safety and efficacy of a treatment Determine optimal trial procedures and assessments Generate hypotheses for future trials Screen potential participants Explanation: Pilot trials are conducted to test trial logistics and procedures before full-scale implementation. Q19: Who is responsible for monitoring safety data during a clinical trial? Sponsor Principal investigator Data safety monitoring board Institutional review board Explanation: The Data Safety Monitoring Board (DSMB) independently reviews trial safety and efficacy data. Q20: What document must be prepared prior to initiating a clinical trial? Informed consent form Study protocol Case report form Statistical analysis plan Explanation: The study protocol outlines all trial details and must be approved before initiation. Q21: What type of clinical trial compares a new treatment to an existing standard treatment? Open label trial Single blind trial Double blind trial Randomized controlled trial Explanation: Randomized controlled trials (RCTs) compare new treatments to existing standards using random assignment to minimize bias. Q22: Which phrase best describes the purpose of a placebo in a clinical trial? To test for side effects of a treatment To act as a comparison against the experimental treatment To determine the efficacy of a treatment To establish adverse event profiles Explanation: Placebos are used as control to help isolate the treatment effect from psychological effects. Q23: Which type of clinical trial requires participants and investigators to remain unaware of treatment assignment? Open label trial Single blind trial Double blind trial Crossover trial Explanation: Double-blind trials help reduce both participant and researcher bias during outcome evaluation. Q24: In which phase of clinical trials is a treatment first tested in humans? Phase 0 Phase 1 Phase 2 Phase 3 Explanation: Phase 1 trials are the first stage of human testing, focusing on safety and dosage. Q25: What type of clinical trial designs assess more than two treatment groups? Parallel design Crossover design Factorial design All of the above Explanation: All listed designs may involve more than two groups depending on structure and comparison. Q26: What methodology is used in clinical trials to randomly assign participants to treatment groups? Blinding Stratification Randomization Block randomization Explanation: Randomization is essential for minimizing allocation bias and confounding. Q27: Why is informed consent regarded as ethically important in clinical trials? To protect participants and their rights To maintain blinding and objectivity of trial To empower researchers over participants To ensure generalizability of findings Explanation: Informed consent ensures participants voluntarily participate with full understanding of risks and benefits. Q28: What is the primary purpose of a pilot clinical trial? Establish safety and efficacy of a treatment Determine optimal trial procedures and assessments Generate hypotheses for future trials Screen potential participants Explanation: Pilot trials are conducted to test trial logistics and procedures before full-scale implementation. Q29: Who is responsible for monitoring safety data during a clinical trial? Sponsor Principal investigator Data safety monitoring board Institutional review board Explanation: The Data Safety Monitoring Board (DSMB) independently reviews trial safety and efficacy data. Q30: What document must be prepared prior to initiating a clinical trial? Informed consent form Study protocol Case report form Statistical analysis plan Explanation: The study protocol outlines all trial details and must be approved before initiation. Q31: What type of clinical trial compares a new treatment to an existing standard treatment? Open label trial Single blind trial Double blind trial Randomized controlled trial Explanation: Randomized controlled trials (RCTs) compare new treatments to existing standards using random assignment to minimize bias. Q32: Which phrase best describes the purpose of a placebo in a clinical trial? To test for side effects of a treatment To act as a comparison against the experimental treatment To determine the efficacy of a treatment To establish adverse event profiles Explanation: Placebos are used as control to help isolate the treatment effect from psychological effects. Q33: Which type of clinical trial requires participants and investigators to remain unaware of treatment assignment? Open label trial Single blind trial Double blind trial Crossover trial Explanation: Double-blind trials help reduce both participant and researcher bias during outcome evaluation. Q34: In which phase of clinical trials is a treatment first tested in humans? Phase 0 Phase 1 Phase 2 Phase 3 Explanation: Phase 1 trials are the first stage of human testing, focusing on safety and dosage. Q35: What type of clinical trial designs assess more than two treatment groups? Parallel design Crossover design Factorial design All of the above Explanation: All listed designs may involve more than two groups depending on structure and comparison. Q36: What methodology is used in clinical trials to randomly assign participants to treatment groups? Blinding Stratification Randomization Block randomization Explanation: Randomization is essential for minimizing allocation bias and confounding. Q37: Why is informed consent regarded as ethically important in clinical trials? To protect participants and their rights To maintain blinding and objectivity of trial To empower researchers over participants To ensure generalizability of findings Explanation: Informed consent ensures participants voluntarily participate with full understanding of risks and benefits. Q38: What is the primary purpose of a pilot clinical trial? Establish safety and efficacy of a treatment Determine optimal trial procedures and assessments Generate hypotheses for future trials Screen potential participants Explanation: Pilot trials are conducted to test trial logistics and procedures before full-scale implementation. Q39: Who is responsible for monitoring safety data during a clinical trial? Sponsor Principal investigator Data safety monitoring board Institutional review board Explanation: The Data Safety Monitoring Board (DSMB) independently reviews trial safety and efficacy data. Q40: What document must be prepared prior to initiating a clinical trial? Informed consent form Study protocol Case report form Statistical analysis plan Explanation: The study protocol outlines all trial details and must be approved before initiation. Submit Retake Quiz Share this post:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)MoreClick to print (Opens in new window)Click to email a link to a friend (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Tumblr (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Mastodon (Opens in new window) Related