1. A 35-year-old man presents with acute hepatitis, nausea, vomiting, and jaundice. Serologic testing is positive for IgM anti-hepatitis E virus (HEV) antibodies. Which of the following is the most appropriate next step in management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
2. A 45-year-old woman with a history of chronic liver disease presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
3. A 60-year-old man with cirrhosis presents with acute decompensation, including ascites and hepatic encephalopathy. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
4. A 50-year-old woman with a history of solid organ transplantation presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
5. A 35-year-old man with no underlying liver disease presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
6. A 65-year-old man with cirrhosis presents with acute decompensation, including variceal bleeding. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
7. A 40-year-old woman with a history of solid organ transplantation presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
8. A 25-year-old man with no underlying liver disease presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
9. A 70-year-old man with cirrhosis presents with acute decompensation, including hepatic encephalopathy. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
10. A 30-year-old woman with a history of solid organ transplantation presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
11. A 45-year-old man with no underlying liver disease presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
12. A 60-year-old man with cirrhosis presents with acute decompensation, including variceal bleeding. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
13. A 35-year-old woman with a history of solid organ transplantation presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
14. A 50-year-old man with no underlying liver disease presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
15. A 65-year-old man with cirrhosis presents with acute decompensation, including hepatic encephalopathy. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
16. A 40-year-old woman with a history of solid organ transplantation presents with acute hepatitis and jaundice. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing
17. A 55-year-old man with cirrhosis presents with acute decompensation, including variceal bleeding. Serologic testing is positive for IgM anti-HEV antibodies. Which of the following is the most appropriate management?
A. Initiate treatment with ribavirin
B. Initiate treatment with pegylated interferon
C. Recommend hospitalization for supportive care
D. Recommend liver transplantation
E. Recommend monitoring with repeat laboratory testing